Yes Altair’s voice in Bloodlines was a huge disappointment for me, since I am one of the few people who actually liked his voice in AC1 (I also love his voice actor in ACR, though). Maybe because I’m not American (not even anglophone) so for me his American accent is not a big issue. I can “hear” it and I also notice the difference between his voice and the voices of the other characters (and their Middle-Eastern accent), but it doesn’t bother me. He had a cold but very sexy tone which I liked and still like a lot.
In Bloodlines… nnngh. I silently suffered through the entire game, due to that horrible voice. I’m sorry for the voice actor, but it’s true. And he wasn’t very good at acting, either. So, yeah… I played it, I took some notes for my fanfic “The grace of chaos” (which is based on Bloodlines)… the end. Once is more than enough! XD